创伤失血性休克中造血祖细胞受损。
Impaired hematopoietic progenitor cells in trauma hemorrhagic shock.
作者信息
Kumar Manoj, Bhoi Sanjeev
机构信息
Department of Emergency Medicine, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi 110029, India.
出版信息
J Clin Orthop Trauma. 2016 Oct-Dec;7(4):282-285. doi: 10.1016/j.jcot.2016.05.013. Epub 2016 Jun 22.
Abstract
Hemorrhagic shock (HS) is the major cause of death during trauma. Mortality due to HS is about 50%. Dysfunction of hematopoietic progenitor cells (HPCs) has been observed during severe trauma and HS. HS induces the elevation of cytokines, granulocyte-colony stimulating factor (G-CSF), peripheral blood HPCs, and circulating catecholamines, and decreases the expression of erythropoietin receptor connected with suppression of HPCs. Impaired HPCs may lead to persistent anemia and risk of susceptibility to infection, sepsis, and MOF. There is a need to reactivate impaired HPCs during trauma hemorrhagic shock.
摘要
失血性休克（HS）是创伤期间死亡的主要原因。HS导致的死亡率约为50%。在严重创伤和HS期间已观察到造血祖细胞（HPC）功能障碍。HS会导致细胞因子、粒细胞集落刺激因子（G-CSF）、外周血HPC和循环儿茶酚胺水平升高，并降低与HPC抑制相关的促红细胞生成素受体的表达。HPC受损可能导致持续性贫血以及易发生感染、败血症和多器官功能衰竭的风险。在创伤性失血性休克期间需要重新激活受损的HPC。
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