西格玛-1受体与神经保护：当前展望及潜在治疗作用 - Suppr

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超能文献

Sigma-1 receptor and neuroprotection: current outlook and potential therapeutic effects.

作者信息

Li Volti Giovanni, Murabito Paolo

机构信息

Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.

Azienda Ospedaliera Universitaria Policlinico "G. Rodolico", University of Catania, Catania, Italy.

出版信息

Neural Regen Res. 2016 Sep;11(9):1392-1393. doi: 10.4103/1673-5374.191200.

DOI:10.4103/1673-5374.191200

PMID:27857729

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5090828/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e7f/5090828/ac23eb956066/NRR-11-1392-g001.jpg

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本文引用的文献

(+)-Pentazocine reduces oxidative stress and apoptosis in microglia following hypoxia/reoxygenation injury.（+）-喷他佐辛可减轻缺氧/复氧损伤后小胶质细胞的氧化应激和凋亡。

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Crystal structure of the human σ1 receptor.人类σ1受体的晶体结构。

Nature. 2016 Apr 28;532(7600):527-30. doi: 10.1038/nature17391. Epub 2016 Apr 4.

Allosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation.SKF83959对σ-1受体的变构调节可抑制小胶质细胞介导的炎症。

J Neurochem. 2015 Sep;134(5):904-14. doi: 10.1111/jnc.13182. Epub 2015 Jun 19.

The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements.西格玛-1 受体可防止细胞氧化应激并激活抗氧化反应元件。

Eur J Pharmacol. 2012 May 5;682(1-3):12-20. doi: 10.1016/j.ejphar.2012.01.030. Epub 2012 Feb 22.

Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats.Sigma-1 受体配体 PRE-084 可减少大鼠栓塞性中风后的梗死体积、神经功能缺损、促炎细胞因子，并增强抗炎细胞因子。

Brain Res Bull. 2011 May 30;85(3-4):219-24. doi: 10.1016/j.brainresbull.2011.03.019. Epub 2011 Mar 29.

Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival.内质网-线粒体界面处的西格玛-1受体伴侣蛋白调节钙离子信号传导和细胞存活。

Cell. 2007 Nov 2;131(3):596-610. doi: 10.1016/j.cell.2007.08.036.

Glutamate-evoked redox state alterations are involved in tissue transglutaminase upregulation in primary astrocyte cultures.谷氨酸诱发的氧化还原状态改变参与原代星形胶质细胞培养中组织转谷氨酰胺酶的上调。

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