Liu Bin, Jiang Yin-Hua, Xiao Jian, Li Xiao-Kun
Wenzhou Medical University. Wenzhou 355035, Zhejiang Province, China. E-mail:
Shanghai Kou Qiang Yi Xue. 2016 Aug;25(4):497-499.
To observe the effect of recombinant human basic fibroblast growth factor (bFGF) atomization inhalation on postoperative sore throat following oral and maxillofacial operation under general anethesia.
Forty patients in whom oral and maxillofacial operation trachea was removed under general anesthesia were randomly divided into treatment and control groups; the treatment group received bFGF 35000IU + normal saline 20 mL, compression inhalation, day 1, every 20min, continued for 3 d; the control group was given normal saline 5 mL + dexamethasone 5 mg + gentamicin 80000 U + chymotrypsin 4000 U, compression inhalation, twice a day, every 20 min, continued for 3 d. Occurrence of postoperative sore throat 12 h after operation was recorded and visual analog scale (VAS) of sore throat (swallowing) 12,24,48,72 h after operation was measured. SPSS l4.0 software package was used for statistical analysis.
The incidence of sore throat in the treatment group was significantly lower than that in the control group (P<0.01) 12 h after operation; sore throat (swallowing) VAS 12,24,48 and 72 h after operation in the treatment group were significantly lower than that in the control group (P<0.05).
bFGF atomization inhalation can reduce the incidence of sore throat and sore throat level in oral and maxillofacial surgery after endotracheal intubation.
观察重组人碱性成纤维细胞生长因子（bFGF）雾化吸入对全身麻醉下口腔颌面手术后咽痛的影响。
将40例全身麻醉下行口腔颌面手术气管插管拔除的患者随机分为治疗组和对照组；治疗组给予bFGF 35000IU+生理盐水20mL，压缩雾化吸入，术后第1天，每20分钟1次，持续3天；对照组给予生理盐水5mL+地塞米松5mg+庆大霉素80000U+糜蛋白酶4000U，压缩雾化吸入，每日2次，每次20分钟，持续3天。记录术后12小时咽痛的发生情况，并测量术后12、24、48、72小时咽痛（吞咽时）的视觉模拟评分（VAS）。采用SPSS 14.0软件包进行统计学分析。
术后12小时，治疗组咽痛发生率显著低于对照组（P<0.01）；治疗组术后12、24、48及72小时咽痛（吞咽时）VAS评分显著低于对照组（P<0.05）。
bFGF雾化吸入可降低气管插管后口腔颌面外科手术咽痛的发生率及咽痛程度。
