Diluvio Laura, Bavetta Mauro, Di Prete Monia, Orlandi Augusto, Bianchi Luca, Campione Elena
Department of Dermatology, University of Rome Tor Vergata, Viale Oxford 81, Rome, 00133, Italy.
Department of Anatomic Pathology, University of Rome Tor Vergata, Viale Oxford 81, Rome, 00133, Italy.
Dermatol Ther. 2017 Jan;30(1). doi: 10.1111/dth.12438. Epub 2016 Nov 12.
Basal cell carcinoma is the most common non-melanoma skin cancer, and its incidence continues to raise. Although surgery can be considered the mainstay of therapy, new current pharmacological options are available and focus on tumor eradication, maximizing cosmetic results, and functional capacity. Several studies have recently reported on safety and efficacy of topical ingenol mebutate gel, a derivative of the plant Euphorbia Peplus, used to treat actinic keratosis and superficial basal cell carcinoma. In our knowledge, we report for the first time the dermoscopic evaluation of outcome and monitoring of superficial pigmented and non-pigmented basal cell carcinomas in four patients treated by this novel non-ablative agent. Ingenol mebutate gel therapy has showed to be effective and without important side-effects for pigmented and non-pigmented superficial basal cell carcinomas. We emphasize the usefulness of dermoscopy in supporting the clinical diagnosis and excluding the presence of tumor residue or recurrence. In a future scenario, we hope it will be soon possible to follow-up the lesions, after treatment, avoiding post-control biopsy punch.
基底细胞癌是最常见的非黑色素瘤皮肤癌，其发病率持续上升。尽管手术可被视为主要治疗手段，但目前有新的药物选择，重点在于根除肿瘤、最大化美容效果和功能能力。最近有几项研究报道了外用鬼臼毒素酯凝胶的安全性和有效性，该凝胶是大戟科植物续随子的衍生物，用于治疗光化性角化病和浅表基底细胞癌。据我们所知，我们首次报告了对四名接受这种新型非消融剂治疗的浅表色素性和非色素性基底细胞癌患者的结局进行皮肤镜评估及监测情况。鬼臼毒素酯凝胶疗法已显示对色素性和非色素性浅表基底细胞癌有效且无重要副作用。我们强调皮肤镜在支持临床诊断以及排除肿瘤残留或复发方面的有用性。在未来的情况下，我们希望治疗后不久就能对病变进行随访，避免进行术后对照活检打孔。
