Lamarche Florence, Job Anne-Sophie, Deman Pierre, Bhattacharjee Manik, Hoffmann Dominique, Gallazzini-Crépin Céline, Bouvard Sandrine, Minotti Lorella, Kahane Philippe, David Olivier
Univ. Grenoble Alpes, Grenoble Institute of Neuroscience, GIN, Grenoble, France.
Inserm, U1216, Grenoble, France.
Epilepsia. 2016 Dec;57(12):2045-2055. doi: 10.1111/epi.13592. Epub 2016 Nov 8.
Interictal [18F]fluorodeoxyglucose-positron emission tomography (FDG-PET) is used in the presurgical evaluation of patients with drug-resistant focal epilepsy. We aimed at clarifying its relationships with ictal high-frequency oscillations (iHFOs) shown to be a relevant marker of the seizure-onset zone.
We studied the correlation between FDG-PET and epileptogenicity maps in an unselected series of 37 successive patients having been explored with stereo-electroencephalography (SEEG).
At the group level, we found a significant correlation between iHFOs and FDG-PET interictal hypometabolism only in cases of temporal lobe epilepsy. This correlation was found with HFOs, and the same comparison between FDG-PET and ictal SEEG power of lower frequencies during the same epochs did not show the same significance.
This finding suggests that interictal FDG-PET and ictal HFOs may share common underlying pathophysiologic mechanisms of ictogenesis in temporal lobe epilepsy, and combining both features may help to identify the seizure-onset zone.
发作间期[18F]氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）用于药物难治性局灶性癫痫患者的术前评估。我们旨在阐明其与发作期高频振荡（iHFOs）的关系，iHFOs被证明是癫痫发作起始区的一个相关标志物。
我们在37例连续接受立体脑电图（SEEG）检查的未选择患者系列中研究了FDG-PET与致痫性图谱之间的相关性。
在组水平上，我们发现仅在颞叶癫痫病例中，iHFOs与FDG-PET发作间期低代谢之间存在显著相关性。这种相关性在HFOs中被发现，并且在相同时间段内FDG-PET与发作期SEEG较低频率功率之间的相同比较未显示出相同的显著性。
这一发现表明，发作间期FDG-PET和发作期HFOs可能在颞叶癫痫的发作发生中具有共同的潜在病理生理机制，并且结合这两个特征可能有助于识别癫痫发作起始区。
Zotero 插件
