Nikolaian L T, Karapetian E T, Pospelov L E
Probl Tuberk. 1989(3):49-51.
Sixty patients with infiltrative tuberculosis of the lungs showing different dynamics of the process were examined. In the patients with unfavourable process of the disease antigens A2, B13, B16 and DR2 were more frequent than in the patients with favourable process of the disease in whom antigens A9, B12, Cw4 and DR5 were more frequent. It suggested that the presence of antigen DR2 was a certain risk factor as to development of tuberculosis and its presence in tuberculous patients could indicate unfavourable outcome of the disease. The levels of the specific antituberculous antibodies to PPD were also indicative of favourable and unfavourable processes of pulmonary tuberculosis.
对60例肺部浸润性肺结核患者进行了检查,这些患者的病情呈现出不同的发展动态。在病情发展不利的患者中,抗原A2、B13、B16和DR2出现的频率高于病情发展有利的患者,而在病情发展有利的患者中,抗原A9、B12、Cw4和DR5出现的频率更高。这表明抗原DR2的存在是结核病发展的一个特定风险因素,其在结核病患者中的出现可能预示着疾病的不良预后。针对PPD的特异性抗结核抗体水平也可指示肺结核病情的有利和不利发展过程。