Teran L, Selman M, Mendoza M, Rubio H, Bañales J L, Granados J
Ann Clin Res. 1985;17(1):40-2.
We studied the HLA-A, B,C and DR antigens in 50 patients with advanced pulmonary tuberculosis in an effort to detect some genetic factors which may predispose to the development of this disease. We found a decrease in HLA-A3, A9, B5, B8, B13, B17 and B27. The incidence of "double blank" antigens in the locus A was 18% (2.5% in controls, p less than 0.0005) in the locus B 16% (1.5% in controls, p less than 0.0005) and 28% in the DR locus (7% in controls, p less than 0.0005). Our results suggest that the cells responsible for the immune response in patients with tuberculosis appear to have a diminished number of HLA antigens serologically determined. That phenomenon could be explained by several hypothesis like poor expression of these proteins or masking for another substance. In spite of the mechanism, this abnormal membrane expression of HLA antigens could be important for the development of the disease since the cell-cell interactions critical for the mounting of an adequate immune response might not be appropriate.
我们对50例晚期肺结核患者的HLA - A、B、C和DR抗原进行了研究，以检测可能易患该病的一些遗传因素。我们发现HLA - A3、A9、B5、B8、B13、B17和B27有所减少。A位点“双空白”抗原的发生率为18%（对照组为2.5%，p<0.0005），B位点为16%（对照组为1.5%，p<0.0005），DR位点为28%（对照组为7%，p<0.0005）。我们的结果表明，肺结核患者中负责免疫反应的细胞表面通过血清学检测确定的HLA抗原数量似乎减少。这种现象可以用几种假说来解释，比如这些蛋白质表达不佳或被其他物质掩盖。不管其机制如何，HLA抗原这种异常的膜表达可能对疾病的发展很重要，因为对产生充分免疫反应至关重要的细胞间相互作用可能不合适。
