Department of Dermatology, Academic Medical Centre, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.
Department of Dermatology, VU University Medical Centre, 1081 HV Amsterdam, The Netherlands.
Contact Dermatitis. 2017 Mar;76(3):151-159. doi: 10.1111/cod.12711. Epub 2016 Nov 11.
Allergic contact dermatitis is known to occur in children with and without atopic dermatitis, but more data are needed on contact sensitization profiles in these two groups.
To identify frequent allergens in children with and without atopic dermatitis suspected of having allergic contact dermatitis.
A retrospective analysis of children aged 0-17 years patch tested between 1996 and 2013 was performed.
Of all 1012 children tested because of suspected contact dermatitis, 46% developed one or more positive reactions, the proportions for children with (n = 526) and without (n = 395) atopic dermatitis being 48% and 47%, respectively. Children with atopic dermatitis reacted more often to lanolin alcohol (30% pet., p = 0.030), Amerchol L-101 (p = 0.030), and fragrances [fragrance mix I (p = 0.048) and Myroxylon pereirae (p = 0.005)]. Allergens outside the European baseline series that frequently gave positive reactions in these groups included cocamidopropyl betaine and Amerchol L-101. Reactivity to these allergens was significantly more common in atopic dermatitis children.
Sensitization prevalences in children with and without atopic dermatitis were similar, but children with atopic dermatitis reacted significantly more often to lanolin alcohol and fragrances. Testing with additional series besides the European baseline series may be necessary, as reactions to, for example, cocamidopropyl betaine and Amerchol L-101 may otherwise be missed.
已知特应性皮炎患儿和非特应性皮炎患儿均会发生过敏性接触性皮炎，但仍需更多数据来阐明这两组患儿的接触致敏谱。
确定疑似过敏性接触性皮炎的特应性皮炎患儿和非特应性皮炎患儿中常见的致敏原。
对 1996 年至 2013 年间接受斑贴试验的 0-17 岁儿童进行回顾性分析。
所有 1012 例因疑似接触性皮炎而接受斑贴试验的儿童中，46%出现 1 种或多种阳性反应，特应性皮炎患儿（n=526）和非特应性皮炎患儿（n=395）的比例分别为 48%和 47%。特应性皮炎患儿对羊毛脂醇（30% pet.，p=0.030）、Amerchol L-101（p=0.030）和香料[香料混合物 I（p=0.048）和 Myroxylon pereirae（p=0.005）]的反应更为频繁。这些患儿中，欧洲斑贴试验系列之外的过敏原，包括椰油酰胺丙基甜菜碱和 Amerchol L-101，也常引起阳性反应。这些过敏原在特应性皮炎患儿中的反应更为常见。
特应性皮炎患儿和非特应性皮炎患儿的致敏率相似，但特应性皮炎患儿对羊毛脂醇和香料的反应更为频繁。除欧洲斑贴试验系列之外，可能还需要进行其他系列的检测，否则可能会遗漏对椰油酰胺丙基甜菜碱和 Amerchol L-101等过敏原的反应。
