Al Mokadem S, Ghonemy S, Zidan A, Abd El Aleem G
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Clin Exp Dermatol. 2017 Jan;42(1):30-35. doi: 10.1111/ced.12976. Epub 2016 Nov 11.
Pityriasis rosea (PR) is an exanthematous disease related to reactivation of human herpes virus (HHV) types 6 and 7. The pathogenesis and cytokine profile of PR are still poorly understood.There is a large amount of evidence indicating a viral aetiology for PR.
To measure the serum level of interleukin (IL)-22, a cytokine expressed by T helper (Th)17 cells in patients with PR to explore the possible association of IL-22 with the pathogenesis of the disease.
This case-control study enrolled 25 patients with PR (mean ± SD age 20 ± 12 years) and a control group of 25 apparently healthy individuals (mean age 18 ± 12.1 years). Blood samples were collected from both patients and controls to measure serum IL-22. Scoring of PR was performed using the Pityriasis Rosea Severity Score (PRSS).
There was a statistically significant difference in IL-22 serum level between the patient and control groups. The IL-22 serum level increased with increase in disease severity (PRSS), extent and duration.
Through its proinflammatory cytokines, IL-22 plays a role in the inflammatory process of PR.
玫瑰糠疹（PR）是一种与人类疱疹病毒6型和7型再激活相关的发疹性疾病。PR的发病机制和细胞因子谱仍知之甚少。有大量证据表明PR的病毒病因。
检测玫瑰糠疹患者中辅助性T（Th）17细胞表达的细胞因子白细胞介素（IL）-22的血清水平，以探讨IL-22与该病发病机制的可能关联。
本病例对照研究纳入了25例玫瑰糠疹患者（平均±标准差年龄20±12岁）和25名明显健康个体组成的对照组（平均年龄18±12.1岁）。采集患者和对照组的血样以检测血清IL-22。使用玫瑰糠疹严重程度评分（PRSS）对玫瑰糠疹进行评分。
患者组和对照组之间的IL-22血清水平存在统计学显著差异。IL-22血清水平随疾病严重程度（PRSS）、范围和持续时间的增加而升高。
IL-22通过其促炎细胞因子在玫瑰糠疹的炎症过程中发挥作用。
