玫瑰糠疹患者血清白细胞介素-36：疾病严重程度的潜在生物标志物
Serum Interleukin-36 in Pityriasis Rosea: A Potential Biomarker for Disease Severity.
作者信息
Sanad Eman M, Ibrahim Mays, Rachwan Maha, Shams Ghada M
机构信息
Dr. Sanad and Dr. Shams are with the Department of Dermatology, Venereology and Andrology, and Faculty of Medicine at Benha University, in Banha, Egypt.
Mr. Ibrahim is with the Faculty of Medicine at Benha University in Banha, Egypt.
出版信息
J Clin Aesthet Dermatol. 2023 May;16(5):43-46.
OBJECTIVE
Pityriasis rosea (PR) is a self-limiting acute rash with unclear etiology and pathogenesis. The cytokine profile of PR is an infrequently investigated field of research. The aim of this study was to assess the level of IL-36 in sera of patients with PR and its possible interrelation with disease severity.
METHODS
Forty patients with PR were included in this case-control study, and 40 comparable healthy control subjects. Severity was assessed using pityriasis rosea severity score (PRSS) and serum IL-36 was assessed using ELISA.
RESULTS
Serum IL-36 was significantly higher in patients (30.36±12.35) pg/mL compared to control subjects (18.76±10.24) pg/mL (P=0.003). It correlates positively with severity as assessed by PRSS (= 627, = 0.003). Patients who reported a history of COVID-19 had significantly higher levels of IL-36 (32.66±11.79) pg/mL compared to those who have not (17.33±2.08) pg/mL (= 0.000).
CONCLUSION
Serum IL-36 could be considered a potential biomarker for pityriasis rosea that correlates with the disease severity.
目的
玫瑰糠疹（PR）是一种病因和发病机制不明的自限性急性皮疹。玫瑰糠疹的细胞因子谱是一个较少被研究的领域。本研究的目的是评估玫瑰糠疹患者血清中白细胞介素-36（IL-36）水平及其与疾病严重程度的可能相关性。
方法
本病例对照研究纳入了40例玫瑰糠疹患者和40例匹配的健康对照者。使用玫瑰糠疹严重程度评分（PRSS）评估疾病严重程度，采用酶联免疫吸附测定（ELISA）法检测血清IL-36水平。
结果
患者血清IL-36水平（30.36±12.35）pg/mL显著高于对照者（18.76±10.24）pg/mL（P = 0.003）。血清IL-36水平与PRSS评估的疾病严重程度呈正相关（r = 0.627，P = 0.003）。有新型冠状病毒肺炎（COVID-19）病史的患者血清IL-36水平（32.66±11.79）pg/mL显著高于无该病史者（17.33±2.08）pg/mL（P = 0.000）。
结论
血清IL-36可被视为玫瑰糠疹的潜在生物标志物，且与疾病严重程度相关。
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