Ponte C D, Lewis M J, Rogers J S
School of Pharmacy, West Virginia University Health Sciences Center, Morgantown 26506.
DICP. 1989 Feb;23(2):140-2. doi: 10.1177/106002808902300207.
A 27-year-old white woman developed Heinz-body hemolytic anemia following multiple courses of oral phenazopyridine and trimethoprim-sulfamethoxazole. Her diagnosis was supported by the finding of bite cells on peripheral blood smear. The patient's rapid recovery and reversal of abnormal laboratory parameters were consistent with an acquired hemolytic disorder. This case should sensitize the clinician to the development of drug-induced oxidative hemolysis, its clinical features, and its reversibility. It is also important that the clinician recognize those drugs capable of causing this disorder and appreciate the methods available to establish the diagnosis.
一名27岁的白人女性在多次口服非那吡啶和甲氧苄啶-磺胺甲恶唑后发生了海因茨小体溶血性贫血。外周血涂片发现咬痕细胞支持了她的诊断。患者的快速康复以及异常实验室指标的逆转与获得性溶血性疾病相符。该病例应使临床医生对药物性氧化溶血的发生、临床特征及其可逆性保持警觉。临床医生认识到那些能够引起这种疾病的药物并了解用于确立诊断的可用方法也很重要。
