Langer Nico, Lindigkeit Rainer, Schiebel Hans-Martin, Papke Uli, Ernst Ludger, Beuerle Till
Institute of Pharmaceutical Biology, Technische Universität Braunschweig, Mendelssohnstr. 1, 38106 Braunschweig, Germany.
Chemistry Department, Central Mass Spectrometry Laboratory, Technische Universität Braunschweig, Hagenring 30, 38106 Braunschweig, Germany.
Forensic Sci Int. 2016 Dec;269:31-41. doi: 10.1016/j.forsciint.2016.10.023. Epub 2016 Nov 4.
In February 2016, nine "spice-like" products from German language internet shops were analyzed. In total, eight different synthetic cannabinoids were identified by gas chromatography-mass spectrometry (GC-MS), namely THJ-018, THJ-2201, MAB-CHMINACA, 5F-ADB, 5Cl-AKB48 (syn.: 5C-AKB48), 4-pentenyl-AKB48, MDMB-CHMICA and 5F-AB-PINACA. For the majority of products only one synthetic cannabinoid was identified as the active ingredient, while two products contained 2 and 5 compounds, respectively. For some of the identified cannabinoids (MAB-CHMINACA, 5Cl-AKB48 and 4-pentenyl-AKB48) no or only insufficient physico-chemical data were available in literature. To our knowledge 5Cl-AKB48 and 4-pentenyl-AKB48 were found for the first time in commercially available products, hence an in-depth characterization of these compounds by NMR, EI-MS, ESI-MS/MS, IR- and UV spectroscopy was conducted. In addition, all synthetic cannabinoids were quantified by a GC-MS method using JWH-018 as internal standard and the corresponding response factors to calculate the total amount of all synthetic cannabinoids in the commercial smoking mixtures. The content of synthetic cannabinoids in the investigated products ranged from 23 to 120mg/g (average: 57mg/g), while individual compounds ranged from 1 to 120mg/g.
2016年2月，对来自德语互联网商店的9种“香料类”产品进行了分析。通过气相色谱-质谱联用仪（GC-MS）共鉴定出8种不同的合成大麻素，即THJ-018、THJ-2201、MAB-CHMINACA、5F-ADB、5Cl-AKB48（同义词：5C-AKB48）、4-戊烯基-AKB48、MDMB-CHMICA和5F-AB-PINACA。对于大多数产品，仅鉴定出一种合成大麻素作为活性成分，而有两种产品分别含有2种和5种化合物。对于某些已鉴定出的大麻素（MAB-CHMINACA、5Cl-AKB48和4-戊烯基-AKB48），文献中没有或仅有不足的物理化学数据。据我们所知，5Cl-AKB48和4-戊烯基-AKB48首次在市售产品中被发现，因此通过核磁共振（NMR）、电子轰击质谱（EI-MS）、电喷雾串联质谱（ESI-MS/MS）、红外光谱（IR）和紫外光谱（UV）对这些化合物进行了深入表征。此外，所有合成大麻素均采用以JWH-018为内标的GC-MS方法进行定量，并使用相应的响应因子来计算商业吸烟混合物中所有合成大麻素的总量。所研究产品中合成大麻素的含量范围为23至120mg/g（平均：57mg/g），而单个化合物的含量范围为1至120mg/g。
