慢性淋巴细胞白血病的诊断与治疗：巴西慢性淋巴细胞白血病研究组的建议
Diagnosis and treatment of chronic lymphocytic leukemia: recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia.
作者信息
Rodrigues Celso Arrais, Gonçalves Matheus Vescovi, Ikoma Maura Rosane Valério, Lorand-Metze Irene, Pereira André Domingues, Farias Danielle Leão Cordeiro de, Chauffaille Maria de Lourdes Lopes Ferrari, Schaffel Rony, Ribeiro Eduardo Flávio Oliveira, Rocha Talita Silveira da, Buccheri Valeria, Vasconcelos Yuri, Figueiredo Vera Lúcia de Piratininga, Chiattone Carlos Sérgio, Yamamoto Mihoko
机构信息
Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil; Hospital Sírio Libanês, São Paulo, SP, Brazil.
Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil; Fleury Medicina e Saúde, São Paulo, SP, Brazil.
出版信息
Rev Bras Hematol Hemoter. 2016 Oct-Dec;38(4):346-357. doi: 10.1016/j.bjhh.2016.07.004. Epub 2016 Aug 20.
Chronic lymphocytic leukemia is characterized by clonal proliferation and progressive accumulation of B-cell lymphocytes that typically express CD19, CD5 and CD23. The lymphocytes usually infiltrate the bone marrow, peripheral blood, lymph nodes, and spleen. The diagnosis is established by immunophenotyping circulating B-lymphocytes, and prognosis is defined by two staging systems (Rai and Binet) established by physical examination and blood counts, as well as by several biological and genetic markers. In this update, we present the recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia for the diagnosis and treatment of chronic lymphocytic leukemia. The following recommendations are based on an extensive literature review with the aim of contributing to more uniform patient care in Brazil and possibly in other countries with a similar social-economic profile.
慢性淋巴细胞白血病的特征是B淋巴细胞的克隆性增殖和渐进性积聚，这些B淋巴细胞通常表达CD19、CD5和CD23。淋巴细胞通常浸润骨髓、外周血、淋巴结和脾脏。通过对循环B淋巴细胞进行免疫表型分析来确诊，预后则由通过体格检查和血细胞计数建立的两个分期系统（Rai和Binet）以及几个生物学和遗传标志物来定义。在本次更新中，我们展示了巴西慢性淋巴细胞白血病研究小组关于慢性淋巴细胞白血病诊断和治疗的建议。以下建议基于广泛的文献综述，旨在促进巴西以及其他社会经济状况相似的国家提供更统一的患者护理。
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