Qian Li-Ren, Shen Jian-Liang
Department of Hematology, Navy General Hospital, Beijing, China.
Med Gas Res. 2016 Oct 14;6(3):177-179. doi: 10.4103/2045-9912.191366. eCollection 2016 Jul-Sep.
The incidence of chronic graft-versus-host-disease is rising year by year, which has become the leading cause of non-transplantation related death and has become the most difficult complication of allogeneic hematopoietic stem cell transplantation to deal with. Inflammation and fibrosis play dominant roles in the pathogenesis of chronic graft-versus-host-disease. Studies have shown that molecular hydrogen has anti-inflammatory, antioxidant, anti-fibrosis effects. Therefore, we hypothesized that molecular hydrogen may have therapeutic effects on chronic graft-versus-host-disease. Here, we report a patient with severe chronic graft-versus-host-disease successfully treated by drinking hydrogen rich water which may be a safe and effective method for chronic graft-versus-host-disease.
慢性移植物抗宿主病的发病率逐年上升，已成为非移植相关死亡的主要原因，并且成为异基因造血干细胞移植中最难处理的并发症。炎症和纤维化在慢性移植物抗宿主病的发病机制中起主导作用。研究表明，分子氢具有抗炎、抗氧化、抗纤维化作用。因此，我们推测分子氢可能对慢性移植物抗宿主病具有治疗作用。在此，我们报告1例通过饮用富氢水成功治疗的严重慢性移植物抗宿主病患者，这可能是一种治疗慢性移植物抗宿主病的安全有效的方法。
