Enterocyte progenitors can dedifferentiate to replace lost Lgr5 intestinal stem cells revealing that many different progenitor populations can regain stemness.
作者信息
Jones Jennifer C, Dempsey Peter J
机构信息
Cell Biology, Stem Cell and Development Graduate Program, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Cell Biology, Stem Cell and Development Graduate Program, University of Colorado School of Medicine, Aurora, CO 80045, USA; Division of Gastroenterology, Hepatology and Nutrition, Dept. of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA.
出版信息
Stem Cell Investig. 2016 Oct 21;3:61. doi: 10.21037/sci.2016.09.15. eCollection 2016.
Abstract
摘要
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Enterocyte progenitors can dedifferentiate to replace lost Lgr5 intestinal stem cells revealing that many different progenitor populations can regain stemness.肠上皮祖细胞可以去分化以取代丢失的Lgr5肠道干细胞，这表明许多不同的祖细胞群体可以重新获得干性。
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Mouse Label-Retaining Cells Are Molecularly and Functionally Distinct From Reserve Intestinal Stem Cells.小鼠标记保留细胞在分子和功能上与储备肠干细胞不同。
Gastroenterology. 2016 Aug;151(2):298-310.e7. doi: 10.1053/j.gastro.2016.04.049. Epub 2016 May 27.
2
Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters.通过肠上皮细胞谱系后代的可塑性替换丢失的 Lgr5 阳性干细胞。
Cell Stem Cell. 2016 Feb 4;18(2):203-13. doi: 10.1016/j.stem.2016.01.001. Epub 2016 Jan 28.
3
Stem vs non-stem cell origin of colorectal cancer.结直肠癌的干细胞起源与非干细胞起源
Br J Cancer. 2015 Jun 30;113(1):1-5. doi: 10.1038/bjc.2015.214. Epub 2015 Jun 25.
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Krt19(+)/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine.Krt19(+) / Lgr5(-) 细胞是结肠和肠道中具有放射抗性的癌症起始干细胞。
Cell Stem Cell. 2015 Jun 4;16(6):627-38. doi: 10.1016/j.stem.2015.04.013.
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Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.异常的上皮性GREM1表达从干细胞龛外的细胞引发结肠肿瘤发生。
Nat Med. 2015 Jan;21(1):62-70. doi: 10.1038/nm.3750. Epub 2014 Dec 1.
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J Clin Invest. 2014 Mar;124(3):1283-95. doi: 10.1172/JCI73434.
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