Pavlovic Jelena M, Akcali Didem, Bolay Hayrunnisa, Bernstein Carolyn, Maleki Nasim
Department of Neurology, Albert Einstein College of Medicine, Bronx, New York.
Montefiore Headache Center, Bronx, New York.
J Neurosci Res. 2017 Jan 2;95(1-2):587-593. doi: 10.1002/jnr.23903.
Migraine is a common neurological disorder with significantly higher incidence and prevalence in women than men. The presentation of the disease in women is modulated by changes in sex hormones from adolescence to pregnancy and menopause. Yet, the effect of sex influences has often been neglected in both basic and clinical and in clinical management of the disease. In this review, evidence from epidemiological, clinical, animal, and neuroimaging studies on the significance of the sex-related influences in migraine is presented, and the unmet needs in each area are discussed. © 2016 Wiley Periodicals, Inc.
偏头痛是一种常见的神经系统疾病，女性的发病率和患病率显著高于男性。从青春期到怀孕和更年期，女性体内性激素的变化会调节该病的表现。然而，在基础研究、临床研究以及该疾病的临床管理中，性别影响的作用常常被忽视。在这篇综述中，我们展示了来自流行病学、临床、动物和神经影像学研究的证据，以说明性别相关影响在偏头痛中的重要性，并讨论了各个领域尚未满足的需求。© 2016威利期刊公司。
