Speich R, Weber R, Vogt P, Kronauer C M, Lüthy R, Russi E W
Medizinische Klinik, Universitätsspital Zürich.
Schweiz Med Wochenschr. 1989 May 13;119(19):601-12.
The results of 115 bronchoscopic examinations and one autopsy in 105 adults with HIV-infection and pulmonary complications are presented. Whereas 51.7% of the events were caused by Pneumocystis carinii pneumonia (PCP), nonspecific interstitial pneumonitis (NIP) without evidence of an infectious or neoplastic condition was the second most frequent diagnosis in 14 patients (12.1%), four of whom exhibited features of lymphocytic interstitial pneumonia (LIP). The clinical, radiological and prognostic aspects of NIP/LIP, which are very similar to those of PCP, and the possible pathogenesis are discussed. The importance of an adequate diagnostic pulmonary workup is emphasized. We suggest classifying patients with NIP/LIP as stage IV E (CDC) and evaluating the efficacy of a treatment with azidothymidine (AZT) in a controlled clinical study.
本文介绍了对105例感染HIV且有肺部并发症的成人患者进行115次支气管镜检查及1次尸检的结果。其中，51.7%的病例由卡氏肺孢子虫肺炎（PCP）引起，14例患者（12.1%）的第二常见诊断为无感染或肿瘤证据的非特异性间质性肺炎（NIP），其中4例表现为淋巴细胞性间质性肺炎（LIP）特征。文中讨论了NIP/LIP与PCP非常相似的临床、放射学及预后方面情况以及可能的发病机制。强调了进行充分的肺部诊断检查的重要性。我们建议将NIP/LIP患者归类为IV E期（疾病控制与预防中心），并在一项对照临床研究中评估齐多夫定（AZT）治疗的疗效。
