Ohsaka A, Saito K, Mori S, Sakamoto S, Miura Y
Nihon Ketsueki Gakkai Zasshi. 1989 Feb;52(1):63-70.
We describe a case of Lennert's lesion terminating in T cell non-Hodgkin's lymphoma (NHL). A 53-year-old woman showed inguinal lymphadenopathy. This was histologically interpreted as toxoplasmic lymphadenitis. However, Lennert's lesion was diagnosed in subsequent biopsies. Because additional lymphadenopathy and constitutional symptoms were absent, anti-neoplastic therapy was not given. During the five and a half years after the initial biopsy, generalized lymphadenopathy and constitutional symptoms developed. Histological examination of the cervical lymph node disclosed NHL, diffuse, large cell type. Transformed lymphoma cells were confirmed to be of peripheral T cell origin with a helper/inducer phenotype. We speculate that some cases of Lennert's lesion have a potentiality of spontaneous transformation into high grade malignant lymphoma associated with disappearance of epithelioid histiocytes.
我们描述了一例以T细胞非霍奇金淋巴瘤（NHL）告终的 Lennert 病变病例。一名53岁女性出现腹股沟淋巴结病。组织学上最初将其解释为弓形虫淋巴结炎。然而，随后的活检诊断为 Lennert 病变。由于未出现额外的淋巴结病和全身症状，未给予抗肿瘤治疗。在初次活检后的五年半时间里，出现了全身淋巴结病和全身症状。颈部淋巴结的组织学检查显示为弥漫性大细胞型NHL。经证实，转化的淋巴瘤细胞起源于外周T细胞，具有辅助/诱导表型。我们推测，一些 Lennert 病变病例具有自发转化为高级别恶性淋巴瘤并伴有上皮样组织细胞消失的可能性。
