Mariani R, Altarès S, Mengoual R, Richelme C, Albertini M, Sudaka P
Ann Pediatr (Paris). 1989 Apr;36(4):229-32.
Osteocalcin, the most abundant of non-collagen proteins in bone, is produced by osteoblasts and incorporated into the bone matrix. A small amount is circulated in the bloodstream where it can be detected by radioimmunologic assay. Serum assays in 128 children and adolescents showed that serum osteocalcin levels accurately reflect the various stages of statural growth: peak levels were found at three different ages, i.e. infants (21.8 +/- 4.9 ng/ml), children over seven (19.4 +/- 5.2 ng/ml), and adolescents undergoing the early stages of puberty (22.5 +/- 4.2 ng/ml). Although significant differences were found between each age group and the preceding or following group, these results can be applied to individual patients only for longitudinal studies.
骨钙素是骨骼中最丰富的非胶原蛋白，由成骨细胞产生并整合到骨基质中。少量骨钙素在血液循环中，可通过放射免疫测定法检测到。对128名儿童和青少年的血清检测表明，血清骨钙素水平准确反映了身高生长的各个阶段：在三个不同年龄阶段发现了峰值水平，即婴儿期（21.8±4.9纳克/毫升）、七岁以上儿童（19.4±5.2纳克/毫升）以及青春期早期的青少年（22.5±4.2纳克/毫升）。尽管每个年龄组与前一组或后一组之间存在显著差异，但这些结果仅适用于个体患者的纵向研究。
