用于后足融合的胶原蛋白载体中可注射重组人血小板衍生生长因子

Injectable Recombinant Human Platelet-derived Growth Factor in Collagen Carrier for Hindfoot Fusion.

作者信息

Dodd Andrew, Daniels Timothy R

机构信息

Division of Orthopaedic Surgery, St. Michael's Hospital, University of Toronto, 800-55 Queen Street East, Toronto, Ontario M5C 1R6, Canada.

出版信息

Foot Ankle Clin. 2016 Dec;21(4):777-791. doi: 10.1016/j.fcl.2016.07.013.

DOI:10.1016/j.fcl.2016.07.013

PMID:27871411

Abstract

Arthrodesis of the hindfoot is a common procedure for degenerative joint disease and/or severe deformity. Nonunion is a common complication from this procedure, causing an increased burden to the patient and health care system, often resulting in the need for revision surgery. Recombinant human platelet-derived growth factor (rhPDGF) has been shown to be a safe and effective tool to enhance arthrodesis rates in hindfoot surgery while avoiding the potential morbidity of bone grafting. This article provides a review of the role of rhPDGF in hindfoot fusions, and the surgical technique for performing an rhPDGF enhanced double-arthrodesis through a medial approach.

摘要

后足关节融合术是治疗退行性关节疾病和/或严重畸形的常见手术。骨不连是该手术常见的并发症，给患者和医疗系统带来了更大的负担，常常需要进行翻修手术。重组人血小板衍生生长因子（rhPDGF）已被证明是一种安全有效的工具，可提高后足手术的关节融合率，同时避免骨移植的潜在并发症。本文综述了rhPDGF在后足融合术中的作用，以及通过内侧入路进行rhPDGF增强双关节融合术的手术技术。