白细胞介素2可促进白细胞介素2受体的表达以及由非促有丝分裂剂量的伴刀豆球蛋白A刺激的T细胞的增殖。

Interleukin 2 promotes expression of an interleukin 2 receptor and proliferation of T cells stimulated with non-mitogenic dose of concanavalin A.

作者信息

Komada H, Nakabayashi H, Hara M, Hara M, Takahashi T, Morita J, Yoshida T, Takanari H, Izutsu K

机构信息

Department of Pathology, Mie University School of Medicine, Japan.

出版信息

Cell Struct Funct. 1989 Apr;14(2):193-7. doi: 10.1247/csf.14.193.

DOI:10.1247/csf.14.193

PMID:2787210

Abstract

Interleukin 2 (IL-2) initiated proliferation of the cells of T-enriched population stimulated with non-mitogenic dose of concanavalin A (Con A), whereas it could not induce proliferation of the cells treated with non-mitogenic lectin wheat germ agglutinin (WGA). Use of monoclonal antibody (MAb) directed against interleukin 2 receptor (IL-2R) showed that IL-2 significantly increased expression of IL-2R on the cells of T-enriched population stimulated with Con A, whereas it could not cause any significant enhancement of expression of IL-2R on the cells treated with WGA. We concluded that IL-2 activated T cells in combination with non-mitogenic does of Con A, and induced both expression of IL-2R and proliferation.

摘要

白细胞介素2（IL-2）能使在非促有丝分裂剂量的伴刀豆球蛋白A（Con A）刺激下的富含T细胞群体的细胞发生增殖，然而它不能诱导用非促有丝分裂凝集素麦胚凝集素（WGA）处理的细胞增殖。使用针对白细胞介素2受体（IL-2R）的单克隆抗体（MAb）表明，IL-2能显著增加在Con A刺激下的富含T细胞群体的细胞上IL-2R的表达，而它不能使在用WGA处理的细胞上IL-2R的表达有任何显著增强。我们得出结论，IL-2与非促有丝分裂剂量的Con A联合激活T细胞，并诱导IL-2R的表达和细胞增殖。