通过COPII依赖性转运调控表皮生长因子受体（EGFR）的表面水平
Regulation of EGFR surface levels by COPII-dependent trafficking.
作者信息
Farhan Hesso
机构信息
Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, 0372 Oslo, Norway
出版信息
J Cell Biol. 2016 Nov 21;215(4):441-443. doi: 10.1083/jcb.201611014. Epub 2016 Nov 8.
Cell surface levels of epidermal growth factor receptors (EGFRs) are thought to be controlled mainly by endocytic trafficking, with biosynthetic EGFR trafficking presumed to be a constitutive and unregulated process. However, Scharaw et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201601090) demonstrate a role for inducible COPII trafficking in controlling EGFR surface levels.
表皮生长因子受体（EGFRs）的细胞表面水平被认为主要受内吞运输调控，生物合成的EGFR运输被假定为一个组成性且不受调控的过程。然而，Scharaw等人（2016年，《细胞生物学杂志》http://dx.doi.org/10.1083/jcb.201601090）证明了诱导性COPII运输在控制EGFR表面水平方面的作用。
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