Sato Takeshi, Tanaka Toshihiro, Nishiofuku Hideyuki, Fukuoka Yasushi, Sakaguchi Hiroshi, Masada Tetsuya, Tatsumoto Shota, Marugami Nagaaki, Takano Masato, Yamato Ichiro, Sho Masayuki, Ohbayashi Chiho, Hirai Toshiko, Kichikawa Kimihiko
Department of Radiology, IVR CenterNara Medical University, 840 Shijo-cho, Kashihara, 634-8522, Japan.
Department of Radiology, South Nara General Medical Center, Oyodo, Japan.
Cardiovasc Intervent Radiol. 2017 Mar;40(3):438-444. doi: 10.1007/s00270-016-1512-1. Epub 2016 Nov 21.
The purpose of this study is to evaluate the pharmacokinetics and histopathological findings of transarterial chemoembolization (TACE) using cisplatin powder mixed with degradable starch microspheres (DSM) (Cis/DSM-TACE) compared with cisplatin arterial infusion (Cis-AI).
Eighteen rabbits with VX2 liver tumors were divided into two groups: Cis/DSM-TACE (n = 9) and Cis-AI (n = 9) groups. In the Cis/DSM-TACE group, a mixture of cisplatin powder and DSM was injected until stasis of hepatic arterial flow was achieved. In the Cis-AI group, cisplatin solution was infused.
The platinum concentrations in VX2 tumors in the Cis/DSM-TACE group at 24 and 72 h were significantly elevated compared with those in the Cis-AI group (P = .016 and .019, respectively). There were no significant differences in the platinum concentrations in plasma. Histopathological examination revealed the presence of several microspheres inside the tumors at 1 h, which completely disappeared at 24 h. Tumor cell apoptosis at 1 h in the Cis/DSM-TACE group was more frequently observed compared with that in the Cis-AI group (P = .006).
TACE using cisplatin powder mixed with DSM provides a higher drug concentration in tumors, thereby achieving stronger antitumor effects compared with arterial infusion of cisplatin solution.
本研究旨在评估与顺铂动脉灌注（Cis-AI）相比，使用与可降解淀粉微球（DSM）混合的顺铂粉末进行经动脉化疗栓塞（TACE）（Cis/DSM-TACE）的药代动力学和组织病理学结果。
18只患有VX2肝肿瘤的兔子被分为两组：Cis/DSM-TACE组（n = 9）和Cis-AI组（n = 9）。在Cis/DSM-TACE组中，注射顺铂粉末和DSM的混合物，直至肝动脉血流停滞。在Cis-AI组中，输注顺铂溶液。
与Cis-AI组相比，Cis/DSM-TACE组在24小时和72小时时VX2肿瘤中的铂浓度显著升高（分别为P = 0.016和0.019）。血浆中的铂浓度没有显著差异。组织病理学检查显示，在1小时时肿瘤内存在几个微球，在24小时时完全消失。与Cis-AI组相比，Cis/DSM-TACE组在1小时时更频繁地观察到肿瘤细胞凋亡（P = 0.006）。
与顺铂溶液动脉灌注相比，使用与DSM混合的顺铂粉末进行TACE可在肿瘤中提供更高的药物浓度，从而实现更强的抗肿瘤效果。
