Kumar Rajesh, Srinivasan Radhika, Gupta Nalini, Dey Pranab, Rajwanshi Arvind, Nijhawan Raje, Lal Anupam, Kalra Naveen
Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Department of Radiodiagnosisa and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Diagn Cytopathol. 2017 Jan;45(1):36-42. doi: 10.1002/dc.23636. Epub 2016 Nov 22.
Ultrasound-guided fine-needle aspiration cytology (FNAC) is the standard modality for diagnosis of gallbladder malignant neoplasms. Adenocarcinoma is the most common malignancy; however, other types may also be encountered. The aim of this study was to perform a retrospective analysis of gallbladder malignancies diagnosed on FNAC in the last 5 years to document the cytomorphological spectrum and the variations thereof.
The records of the Department of Cytology, PGIMER were searched from July 2010 to June 2015 and all cases of gallbladder malignancies were analyzed in detail for cytomorphological characteristics. Giemsa and Hematoxylin-Eosin stained slides were evaluated with immunocytochemistry on cell blocks wherever available.
A total of 791 gallbladder FNAC performed in cases of radiologically suspected gallbladder malignancies were evaluated. Gallbladder carcinoma (GBC) was more common in females with a male to female ratio of 1:2.3. Median age was 53.4 years (range 24-85 years); 81 cases (10.2%) were nondiagnostic and 31 (3.9%) were suspicious of malignancy. A total of 645 FNACs were positive for malignancy, out of which there were 619 (96%) adenocarcinoma and 26 cases with unusual malignancies. These included adenosquamous carcinoma (8, 1.2%), squamous cell carcinoma (7, 1.1%), small cell neuroendocrine carcinoma (9, 1.3%), and one case each of undifferentiated carcinoma and Non Hodgkin lymphoma respectively. The unusual malignancies were confirmed on cell block immunocytochemistry.
Adenocarcinoma is most common type of gallbladder malignancy; however, other unusual types of carcinomas occur and in such cases, FNAC supplemented by cell block immunocytochemistry is required for an accurate diagnosis. Diagn. Cytopathol. 2017;45:36-42. © 2016 Wiley Periodicals, Inc.
超声引导下细针穿刺细胞学检查（FNAC）是诊断胆囊恶性肿瘤的标准方法。腺癌是最常见的恶性肿瘤；然而，也可能遇到其他类型。本研究的目的是对过去5年通过FNAC诊断的胆囊恶性肿瘤进行回顾性分析，以记录细胞形态学谱及其变化。
检索2010年7月至2015年6月PGIMER细胞学系的记录，并对所有胆囊恶性肿瘤病例的细胞形态学特征进行详细分析。对吉姆萨和苏木精-伊红染色的玻片，如有可用的细胞块，则进行免疫细胞化学评估。
共评估了791例经放射学怀疑为胆囊恶性肿瘤的胆囊FNAC病例。胆囊癌（GBC）在女性中更为常见，男女比例为1:2.3。中位年龄为53.4岁（范围24 - 85岁）；81例（10.2%）诊断不明确，31例（3.9%）怀疑为恶性肿瘤。共有645例FNAC恶性肿瘤阳性，其中腺癌619例（96%），26例为罕见恶性肿瘤。这些包括腺鳞癌（8例，1.2%）、鳞状细胞癌（7例，1.1%）、小细胞神经内分泌癌（9例，1.3%），以及未分化癌和非霍奇金淋巴瘤各1例。通过细胞块免疫细胞化学证实了这些罕见恶性肿瘤。
腺癌是胆囊恶性肿瘤最常见的类型；然而，也会出现其他罕见类型的癌，在这种情况下，需要FNAC辅以细胞块免疫细胞化学以进行准确诊断。诊断细胞病理学。2017；45:36 - 42。©2016威利期刊公司。
