白细胞介素7在基质细胞依赖性B细胞发育中的产生与功能
Interleukin 7 production and function in stromal cell-dependent B cell development.
作者信息
Sudo T, Ito M, Ogawa Y, Iizuka M, Kodama H, Kunisada T, Hayashi S, Ogawa M, Sakai K, Nishikawa S
机构信息
Biomaterial Research Institute Co. Ltd., Yokohama, Japan.
出版信息
J Exp Med. 1989 Jul 1;170(1):333-8. doi: 10.1084/jem.170.1.333.
Abstract
The role of IL-7 in the stromal cell-dependent B cell development was investigated using two stromal cell clones, ST2 and PA6; the former supports B lymphopoiesis while the latter can not. We demonstrate here that: (a) the ability of the stromal cell clone to produce IL-7 correlates well with the stromal cell activity to support B lymphopoiesis; (b) IL-7 production by ST2 is inducible rather than constitutive; (c) the IL-7-dependent B cell itself is a potent inducer of IL-7 production by ST2; (d) addition of rIL-7 to the PA6 layer renders this in vitro environment B lymphopoietic; and (e) the differentiation from early B progenitor to pre-B cell requires both IL-7 and other stromal cell molecule(s) yet to be identified.
摘要
利用两个基质细胞克隆ST2和PA6研究了白细胞介素-7（IL-7）在基质细胞依赖性B细胞发育中的作用；前者支持B淋巴细胞生成，而后者则不能。我们在此证明：（a）基质细胞克隆产生IL-7的能力与支持B淋巴细胞生成的基质细胞活性密切相关；（b）ST2产生的IL-7是可诱导的而非组成性的；（c）IL-7依赖性B细胞本身是ST2产生IL-7的有效诱导剂；（d）向PA6层添加重组IL-7可使这种体外环境具备B淋巴细胞生成能力；以及（e）从早期B祖细胞到前B细胞的分化既需要IL-7，也需要其他尚未确定的基质细胞分子。
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