Tanaka T, Kaneko Y, Haba F, Katsuta S, Tsutsui K, Tamaki S, Chen D R, Suzuki S, Ueda R, Yamamoto A
3rd Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan.
J Clin Lab Immunol. 1989 Feb;28(2):91-6.
This study was undertaken to examine the blastogenic responses of PBL to Streptococcal preparation OK-432 and its fractions. The results showed that OK-432 and its fractions, Su-PR and PM, have the mitogenic activity against human lymphocytes. The demonstration that PBL which had been cultured with OK-432 expressed IL-2 receptors and the blastogenic responses of PBL to OK-432 were inhibited by anti-IL-2 antibody suggested that IL-2 and IL-2 receptors might play a central role in OK-432-induced proliferation of human lymphocytes.
本研究旨在检测外周血淋巴细胞（PBL）对链球菌制剂OK-432及其组分的增殖反应。结果显示，OK-432及其组分Su-PR和PM对人淋巴细胞具有促有丝分裂活性。用OK-432培养的PBL表达白细胞介素-2（IL-2）受体，且抗IL-2抗体可抑制PBL对OK-432的增殖反应，这表明IL-2和IL-2受体可能在OK-432诱导的人淋巴细胞增殖中起核心作用。
