McEwen Centre for Regenerative Medicine and Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 1L7, Canada.
Department of Internal Medicine, Division of Hematology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Nat Rev Mol Cell Biol. 2017 Jan;18(1):56-67. doi: 10.1038/nrm.2016.127. Epub 2016 Nov 23.
Human pluripotent stem cells (hPSCs) provide an unparalleled opportunity to establish in vitro differentiation models that will transform our approach to the study of human development. In the case of the blood system, these models will enable investigation of the earliest stages of human embryonic haematopoiesis that was previously not possible. In addition, they will provide platforms for studying the origins of human blood cell diseases and for generating de novo haematopoietic stem and progenitor cell populations for cell-based regenerative therapies.
人类多能干细胞（hPSCs）为建立体外分化模型提供了无与伦比的机会，这将改变我们研究人类发育的方式。就血液系统而言，这些模型将使我们能够研究以前不可能的人类胚胎造血的最早阶段。此外，它们还将为研究人类血液疾病的起源以及为基于细胞的再生疗法生成新的造血干细胞和祖细胞群体提供平台。
