作为β-内酰胺酶抑制剂的双乙烯酮类似物。

Diketene analogs as beta-lactamase inhibitor.

作者信息

Tanizawa K, Santoh K, Kanaoka Y

出版信息

Chem Pharm Bull (Tokyo). 1989 Mar;37(3):824-5. doi: 10.1248/cpb.37.824.

DOI:10.1248/cpb.37.824

Abstract

Compounds having a structural analogy with diketene have been synthesized and their potencies as beta-lactamase inhibitors have been studied. Among six compounds so far tested, alpha-phenyl-beta-benzylidene-3-propanolide was shown to be an irreversible inhibitor of the enzyme. The availability of simple monocyclic compounds as beta-lactamase inhibitors is discussed.

摘要

已合成了与双乙烯酮结构类似的化合物，并研究了它们作为β-内酰胺酶抑制剂的效力。在迄今为止测试的六种化合物中，α-苯基-β-亚苄基-3-丙内酯被证明是该酶的不可逆抑制剂。本文讨论了简单单环化合物作为β-内酰胺酶抑制剂的可能性。