6β-溴青霉烷酸使β-内酰胺酶I失活。
6 beta-Bromopenicillanic acid inactivates beta-lactamase I.
作者信息
Knott-Hunziker V, Orlek B S, Sammes P G, Waley S G
出版信息
Biochem J. 1979 Jan 1;177(1):365-7. doi: 10.1042/bj1770365.
Abstract
The inactivation of beta-lactamase I by preparations of 6alpha-bromopenicillanic acid showed unexpected kinetic features that indicated that the active species was the 6beta-epimer. Samples containing 6beta-bromopenicillanic acid have been synthesized and shown to inactivate the enzyme in a rapid stoicheiometric reaction.
摘要
用6α-溴青霉烷酸制剂使β-内酰胺酶I失活呈现出意想不到的动力学特征，这表明活性物质是6β-差向异构体。已合成了含有6β-溴青霉烷酸的样品，并表明其在快速化学计量反应中使该酶失活。
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