Liu Y, Waring P, Müllbacher A
Division of Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra.
Eur J Immunol. 1989 Jun;19(6):1153-5. doi: 10.1002/eji.1830190628.
This report addresses the question whether cytotoxic T cells can cause target cell death in vivo by examining target cell DNA fragmentation. The results show that alloreactive cytotoxic T cells induced significant DNA fragmentation in peritoneal macrophages in vivo and that the DNA fragment was a multiple of 180 +/- 30 bp. Furthermore, the effector cells which caused this characteristic DNA fragmentation were CD8+ T cells. These results demonstrate that cytotoxic T cells can cause target cell death in vivo.
本报告通过检测靶细胞DNA片段化来探讨细胞毒性T细胞在体内是否能导致靶细胞死亡。结果显示，同种反应性细胞毒性T细胞在体内可诱导腹膜巨噬细胞出现显著的DNA片段化，且DNA片段为180 +/- 30 bp的倍数。此外，引起这种特征性DNA片段化的效应细胞是CD8 + T细胞。这些结果表明，细胞毒性T细胞在体内可导致靶细胞死亡。
