Bastakoti Bishnu Prasad, Liao Shih-Hsiang, Inoue Masamichi, Yusa Shin-Ichi, Imura Masataka, Nakashima Kenichi, Wu Kevin C-W, Yamauchi Yusuke
World Premier International (WPI) Research Center for Materials, Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
Department of Chemical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan.
Sci Technol Adv Mater. 2013 Jul 29;14(4):044402. doi: 10.1088/1468-6996/14/4/044402. eCollection 2013 Aug.
Polymeric micelles with core-shell-corona nanoarchitecture were designed for intracellular therapeutic anti-cancer drug carriers. Poly(styrene--acrylic acid--ethylene glycol) (PS--PAA--PEG) asymmetric triblock copolymer underwent self-assembly in aqueous solution to form spherical micelles with hydrophobic PS core, anionic PAA shell and hydrophilic PEG corona. The anti-cancer drug (doxorubicin, DOX) was successfully incorporated into the polymeric micelles. The release experiment confirmed that the release of DOX from the micelles was inhibited at pH 7.4. In contrast, an accelerated release of DOX was observed at mildly acidic conditions such as pH 4.5. The excellent biocompatibility of our PS--PAA--PEG-based micelles made the synthesized nano-carrier best suited for the delivery of anti-cancer drugs.
具有核-壳-冠层纳米结构的聚合物胶束被设计用于细胞内治疗性抗癌药物载体。聚（苯乙烯-丙烯酸-乙二醇）（PS-PAA-PEG）不对称三嵌段共聚物在水溶液中自组装形成具有疏水PS核、阴离子PAA壳和亲水PEG冠层的球形胶束。抗癌药物（阿霉素，DOX）成功地掺入到聚合物胶束中。释放实验证实，在pH 7.4时，DOX从胶束中的释放受到抑制。相反，在轻度酸性条件如pH 4.5下观察到DOX的加速释放。我们基于PS-PAA-PEG的胶束具有优异的生物相容性，使得合成的纳米载体最适合用于抗癌药物的递送。
