CB-Receptor Agonist HU-210 Mimics the Postconditioning Phenomenon of Isolated Heart.

作者信息

Gorbunov A S, Maslov L N, Tsibulnikov S Yu, Khaliulin I G, Tsepokina A V, Khutornaya M V, Kutikhin A G

机构信息

Research Institute for Cardiology, Tomsk, Russia.

出版信息

Bull Exp Biol Med. 2016 Nov;162(1):27-29. doi: 10.1007/s10517-016-3536-6. Epub 2016 Nov 23.

CB receptor agonist HU-210 exhibits an infarction-limiting effect during in vitro reperfusion of the heart after focal ischemia. This effect is paralleled by a decrease in left-ventricular developed pressure and double product. In addition, HU-210 reduces end-diastolic pressure during the reperfusion period, which indirectly attests to reduced Ca overload of cardiomyocytes.