内吗啡肽和β-内啡肽不影响心脏对再灌注致病作用的耐受性。
Endomorphins and β-Endorphin Do Not Affect Heart Tolerance to the Pathogenic Effect of Reperfusion.
作者信息
Mukhomedzyanov A V, Maslov L N, Tsibulnikov S Yu, Pei J M
机构信息
Research Institute of Cardiology, Tomsk, Russia.
Fourth Military Medical University, Xi'an, Shaanxi Province, China.
出版信息
Bull Exp Biol Med. 2016 Nov;162(1):23-26. doi: 10.1007/s10517-016-3535-7. Epub 2016 Nov 23.
Selective agonists of μ- and μ-opioid receptors endomorphin-2 and endomorphin-1 injected intravenously in a dose of 4500 nmol/kg in 5 min before coronary blood flow resumption had no effect on cardiac reperfusion damage. Consequently, μ- and μ-opioid receptors are not involved in the regulation of heart tolerance to reperfusion injury. Nonselective opioid receptor agonist β-endorphin (100 nmol/kg) also did not affect heart tolerance to the pathogenic effect of reperfusion.
在恢复冠状动脉血流前5分钟，以4500 nmol/kg的剂量静脉注射μ-阿片受体和μ-阿片受体的选择性激动剂内吗啡肽-2和内吗啡肽-1，对心脏再灌注损伤没有影响。因此，μ-阿片受体和μ-阿片受体不参与心脏对再灌注损伤耐受性的调节。非选择性阿片受体激动剂β-内啡肽（100 nmol/kg）也不影响心脏对再灌注致病作用的耐受性。
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