由签约公司执行并受行业委托进行的网络荟萃分析。
Network meta-analyses performed by contracting companies and commissioned by industry.
作者信息
Schuit Ewoud, Ioannidis John Pa
机构信息
Stanford Prevention Research Center, Stanford University, 1265 Welch Road, Stanford, CA, 94305, USA.
Meta-Research Innovation Center at Stanford (METRICS), Stanford University, 1070 Arastradero Road, Stanford, CA, 94304, USA.
出版信息
Syst Rev. 2016 Nov 25;5(1):198. doi: 10.1186/s13643-016-0377-3.
BACKGROUND
Industry commissions contracting companies to perform network meta-analysis for health technology assessment (HTA) and reimbursement submissions. Our objective was to estimate the number of network meta-analyses performed by consulting companies contracted by industry, to assess whether they were published, and to explore reasons for non-publication.
METHODS
We searched MEDLINE for network meta-analyses of randomized trials. Papers were included if they had authors affiliated with any contracting company. All identified contracting companies as well as additional ones from the list of the exhibitors at the International Society for Pharmacoeconomics and Outcomes Research, an annual meeting that representatives from many contracting companies attend and exhibit at, were surveyed regarding conduct and publication of network meta-analyses.
RESULTS
In 162 of 822 (20%) network meta-analysis papers, authors were affiliated to 66 contracting companies. Another 36 contracting companies were identified by the exhibitors list. Three companies had no contact information and six merged with others, therefore 93 companies were contacted. Thirty seven out of ninety three (40%) companies responded, and 19 indicated that they had performed a total of 476 network meta-analyses, but only 102 (21%) papers were published. Thirteen companies that disclosed to have conducted 174 network meta-analyses (45 published) provided reasons for non-publication. Of the 129 still unpublished meta-analyses, for 40 there were plans for future publication, for 37 the sponsor did not allow publication, for 16 the contracting companies did not plan to publish the meta-analysis, for another 23 plans were unclear, and the remaining 13 were used as HTA submission. The protocol of the network meta-analysis was publically available from 11/162 (6.8%) network meta-analyses published by authors affiliated with contracting companies.
CONCLUSIONS
There is a prolific sector of professional contracting companies that perform network meta-analyses. Industry commissions many network meta-analyses, but most are not registered before or published after analyses in the scientific literature. Mechanisms to improve publication rates of network meta-analysis commissioned by industry are warranted.
背景
制药行业委托合同研究组织开展网络荟萃分析，用于卫生技术评估（HTA）及报销申请。我们的目的是估计行业委托的咨询公司所开展的网络荟萃分析数量，评估其是否发表，并探究未发表的原因。
方法
我们在MEDLINE数据库中检索随机对照试验的网络荟萃分析文献。若论文作者隶属于任何合同研究组织，则纳入研究。我们对所有识别出的合同研究组织以及从国际药物经济学和结果研究学会参展商名单中获取的其他合同研究组织进行了调查，该年会有许多合同研究组织的代表参会并参展，调查内容涉及网络荟萃分析的开展及发表情况。
结果
在822篇网络荟萃分析论文中，有162篇（20%）的作者隶属于66家合同研究组织。通过参展商名单又识别出另外36家合同研究组织。3家公司没有联系信息，6家公司与其他公司合并，因此共联系了93家公司。93家公司中有37家（40%）进行了回复，其中19家表示他们总共开展了476项网络荟萃分析，但仅发表了102篇（21%）论文。13家披露开展了174项网络荟萃分析（45篇已发表）的公司给出了未发表的原因。在129项仍未发表的荟萃分析中，40项计划未来发表，37项因申办方不允许发表，16项合同研究组织不打算发表该荟萃分析，另外23项计划不明确，其余13项用作HTA申报材料。合同研究组织所属作者发表的11/162（6.8%）项网络荟萃分析的方案可公开获取。
结论
有大量专业合同研究组织开展网络荟萃分析。制药行业委托了许多网络荟萃分析，但大多数在科学文献中既未在分析前注册也未在分析后发表。有必要建立机制提高制药行业委托的网络荟萃分析的发表率。
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