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高血压与肾脏

The Kidney in Hypertension.

机构信息

Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, ASH Comprehensive Hypertension Center, The University of Chicago Medicine, 5841 South Maryland Avenue, MC 1027, Chicago, IL 60637, USA.

Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, ASH Comprehensive Hypertension Center, The University of Chicago Medicine, 5841 South Maryland Avenue, MC 1027, Chicago, IL 60637, USA.

出版信息

Med Clin North Am. 2017 Jan;101(1):207-217. doi: 10.1016/j.mcna.2016.08.001.

Abstract

Hypertension is the second most common cause of chronic kidney disease (CKD) and is a potentiator of kidney failure when accompanying disease. CKD is a common cause of resistant hypertension. Nephropathy progression has dramatically slowed over the past 3 decades from an average of 8 to between 2-3 mL/min per year regardless of diabetes status. The incidence of very high albuminuria as well as progression from high albuminuria very high albuminuria has substantially decreased over the past 3 decades. This improvement relates to better blood pressure control using agents that slow nephropathy as well as better glycemic and cholesterol control.

摘要

高血压是慢性肾脏病(CKD)的第二大常见病因,而且在伴随疾病时会加剧肾衰竭的发生。CKD 是导致抗药性高血压的常见原因。在过去的 30 年中,无论糖尿病的状况如何,肾病的进展速度都明显放缓,从每年平均 8 毫升/分钟至 2-3 毫升/分钟不等。过去 30 年来,极高白蛋白尿的发生率以及从高白蛋白尿向极高白蛋白尿的进展已大大减少。这种改善与使用可减缓肾病进展的药物以及更好地控制血糖和胆固醇有关,从而更好地控制血压。

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