Fagiuoli Stefano, Bruno Raffaele, Debernardi Venon Wilma, Schepis Filippo, Vizzutti Francesco, Toniutto Pierluigi, Senzolo Marco, Caraceni Paolo, Salerno Francesco, Angeli Paolo, Cioni Roberto, Vitale Alessandro, Grosso Maurizio, De Gasperi Andrea, D'Amico Gennaro, Marzano Alfredo
Gastroenterologia Epatologia e Trapiantologia, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Dept. of Infectious Diseases, Hepatology Outpatients Unit, University of Pavia-Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Dig Liver Dis. 2017 Feb;49(2):121-137. doi: 10.1016/j.dld.2016.10.011. Epub 2016 Oct 29.
The trans jugular intrahepatic Porto systemic shunt (TIPS) is no longer viewed as a salvage therapy or a bridge to liver transplantation and is currently indicated for a number of conditions related to portal hypertension with positive results in survival. Moreover, the availability of self-expandable polytetrafluoroethylene (PTFE)-covered endoprostheses has dramatically improved the long-term patency of TIPS. However, since the last updated International guidelines have been published (year 2009) new evidence have come, which have open the field to new indications and solved areas of uncertainty. On this basis, the Italian Association of the Study of the Liver (AISF), the Italian College of Interventional Radiology-Italian Society of Medical Radiology (ICIR-SIRM), and the Italian Society of Anesthesia, Analgesia and Intensive Care (SIAARTI) promoted a Consensus Conference on TIPS. Under the auspices of the three scientific societies, the consensus process started with the review of the literature by a scientific board of experts and ended with a formal consensus meeting in Bergamo on June 4th and 5th, 2015. The final statements presented here were graded according to quality of evidence and strength of recommendations and were approved by an independent jury. By highlighting strengths and weaknesses of current indications to TIPS, the recommendations of AISF-ICIR-SIRM-SIAARTI may represent the starting point for further studies.
经颈静脉肝内门体分流术(TIPS)不再被视为一种挽救性治疗方法或肝移植的桥梁,目前适用于多种与门静脉高压相关的病症,在生存率方面取得了积极成果。此外,可自膨胀的聚四氟乙烯(PTFE)覆膜内支架的应用显著提高了TIPS的长期通畅率。然而,自上次更新的国际指南发布(2009年)以来,新的证据不断涌现,为新的适应症开辟了领域,并解决了一些不确定性领域。在此基础上,意大利肝脏研究协会(AISF)、意大利介入放射学会 - 意大利医学放射学会(ICIR - SIRM)以及意大利麻醉、镇痛与重症监护学会(SIAARTI)发起了一次关于TIPS的共识会议。在这三个科学协会的支持下,共识过程始于由专家科学委员会对文献的审查,并于2015年6月4日和5日在贝加莫举行的正式共识会议上结束。此处呈现的最终声明根据证据质量和推荐强度进行了分级,并得到了一个独立评审团的批准。通过强调当前TIPS适应症的优势和不足,AISF - ICIR - SIRM - SIAARTI的建议可能代表了进一步研究的起点。