[蛋白质-脂质相互作用状态在受刺激膜中对C40-类胡萝卜素构象的作用]

[The role of the state of protein-lipid interactions in stimulated membranes in the conformation of C40-carotenoids].

作者信息

Maksimov G V, Musuralieva G T, Churin A A, Pashchenko V Z

出版信息

Biofizika. 1989 May-Jun;34(3):420-4.

Abstract

It was shown by Raman spectroscopy that conformation of carotenoid in the frog nerve membranes at rest and at propagation of rhythmic excitation depends on the state of protein-lipid interaction modified by exposition of the nerve in solution with trypsin, alpha-chymotrypsin, urea, glutaraldehyde, SH-reagents, isopropanol and system "Fe-ascorbate". It is suggested that the level of the protein-lipid interactions in excitable membranes with the intramembrane potential determines C40-carotenoid conformation at the propagation of rhythmic excitation by he nerve.

摘要

拉曼光谱显示，处于静息状态以及在节律性兴奋传播时，青蛙神经膜中类胡萝卜素的构象取决于神经在胰蛋白酶、α-糜蛋白酶、尿素、戊二醛、硫氢基试剂、异丙醇和“铁-抗坏血酸盐”体系的溶液中暴露后所改变的蛋白质-脂质相互作用状态。有人提出，在具有膜内电位的可兴奋膜中，蛋白质-脂质相互作用的水平在神经节律性兴奋传播时决定了C40-类胡萝卜素的构象。