Director, Center for Sleep and Circadian Biology, Northwestern University, Cook Hall, 2220 Campus Drive, Evanston, IL 60208, USA.
Charles E. and Emma H. Morrison Professor of Biology, Department of Neurobiology, Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL 60201, USA.
Science. 2016 Nov 25;354(6315):992-993. doi: 10.1126/science.aal2613.
The last 20 years have seen the rapid evolution of our understanding of the molecular genes and networks that enable almost all forms of life to generate 24-hour-or circadian-rhythms. One finding has been particularly exciting: that the molecular circadian clock resides in almost all of the cells of the body and that the clock regulates the timing of many cellular and signaling pathways associated with multiple disease states. Such advances represent a new frontier for medicine: circadian medicine.
在过去的 20 年中,我们对分子基因和网络的理解迅速发展,这些基因和网络使几乎所有形式的生命都能产生 24 小时或昼夜节律。有一个发现尤其令人兴奋:分子生物钟存在于身体的几乎所有细胞中,并且生物钟调节与多种疾病状态相关的许多细胞和信号通路的时间安排。这些进展代表了医学的一个新前沿: 生物钟医学。