Yepes Nancy Puerta, Rojo Ana, Gossio Sebastián, Crudo José Luis
Nuclear Regulatory Authority (ARN), Av. del Libertador 8250, Ciudad Autónoma de Buenos Aires C1429BNP, República Argentina.
National Atomic Energy Commission (CNEA), Presbítero González y Aragón 15, Ezeiza B1802AYA, República Argentina.
Radiat Prot Dosimetry. 2017 Apr 1;173(1-3):192-197. doi: 10.1093/rpd/ncw317.
Since 2006, CNEA has been conducting studies on the production, labeling, quality control and NIH mice biodistribution of several radiopharmaceuticals based on 177Lu locally produced. In order to contribute to ensuring the radiation protection of patients, the Internal Dosimetry Laboratory of the ARN has been complementing the preclinical study performing a dose assessment. This assessment included: the activity biodistribution analysis in NIH mice, the estimation of the absorbed dose, the extrapolation of the results to humans, the identification of healthy organs with high risk and the estimation of the maximum activity that can be administered to a patient without exceeding the threshold of radiotoxicity in healthy organs. It can be observed that internal dosimetry assessment has an important role for ensuring radiation protection in patients, since treatment parameters can be optimized out of the estimation of the maximum activity to be administered to the patient.
自2006年以来，阿根廷国家原子能委员会一直在对几种基于本地生产的177镥的放射性药物的生产、标记、质量控制和NIH小鼠生物分布进行研究。为了有助于确保患者的辐射防护，阿根廷放射与核能研究所的内照射剂量测定实验室一直在通过进行剂量评估来补充临床前研究。该评估包括：NIH小鼠体内放射性活度生物分布分析、吸收剂量估计、结果外推至人体、识别高风险健康器官以及估计在不超过健康器官放射性毒性阈值的情况下可给予患者的最大放射性活度。可以看出，内照射剂量测定评估对于确保患者的辐射防护具有重要作用，因为可以根据估计的要给予患者的最大放射性活度来优化治疗参数。
