乳清蛋白补充剂可在减肥手术后很长一段时间内促进女性身体脂肪减少和体重减轻：一项随机对照试验。

Whey Protein Supplementation Enhances Body Fat and Weight Loss in Women Long After Bariatric Surgery: a Randomized Controlled Trial.

作者信息

Lopes Gomes Daniela, Moehlecke Milene, Lopes da Silva Fernanda Bassan, Dutra Eliane Said, D'Agord Schaan Beatriz, Baiocchi de Carvalho Kenia Mara

机构信息

Department of Nutrition, University of Brasilia, Brasilia, Brazil.

Endocrine Division, Porto Alegre Clinical Hospital, University of Rio Grande do Sul, Porto Alegre, RS, Brazil.

出版信息

Obes Surg. 2017 Feb;27(2):424-431. doi: 10.1007/s11695-016-2308-8.

DOI:10.1007/s11695-016-2308-8

PMID:27885532

Abstract

BACKGROUND

The ideal nutritional approach for weight regain after bariatric surgery remains unclear.

OBJECTIVE

The objective of this study is to assess the effect of whey protein supplementation on weight loss and body composition of women who regained weight 24 or more months after bariatric surgery.

METHODS

This is a 16-week open-label, parallel-group, randomized controlled trial of women who regained at least 5 % of their lowest postoperative weight after a Roux-en-Y gastric bypass (RYGB). A total of 34 participants were treated with hypocaloric diet and randomized (1:1) to receive or not supplementation with whey protein, 0.5 g/kg of the ideal body weight. The primary outcomes were changes in body weight, fat free mass (FFM), and fat mass (FM), evaluated by tetrapolar bioelectrical impedance analysis (BIA). Secondary outcomes included resting energy expenditure, blood glucose, lipids, adiponectin, interleukin 6 (IL-6), and cholecystokinin levels. Statistical analyses included generalized estimating equations adjusted for age and physical activity.

RESULTS

Fifteen patients in each group were evaluated: mean age was 45 ± 11 years, body mass index (BMI) was 35.7 ± 5.2 kg/m, and time since surgery was 69 ± 23 months. Protein intake during follow-up increased by approximately 75 % in the intervention group (p = 0.01). The intervention group presented more body weight loss (1.86 kg, p = 0.017), accounted for FM loss (2.78, p = 0.021) and no change in FFM, as compared to controls (gain of 0.42 kg of body weight and 0.6 kg of FM). No differences in secondary outcomes were observed between groups.

CONCLUSIONS

Whey protein supplementation promoted body weight and FM loss in women with long-term weight regain following RYGB.

摘要

背景

减肥手术后体重反弹的理想营养方法仍不明确。

目的

本研究的目的是评估补充乳清蛋白对减肥手术后24个月或更长时间体重反弹女性的体重减轻和身体成分的影响。

方法

这是一项为期16周的开放标签、平行组、随机对照试验，对象为接受Roux-en-Y胃旁路术（RYGB）后体重至少反弹至术后最低体重5%的女性。共有34名参与者接受低热量饮食治疗，并随机（1:1）分为接受或不接受乳清蛋白补充剂组，补充剂量为理想体重的0.5 g/kg。主要结局指标为体重、去脂体重（FFM）和脂肪量（FM）的变化，采用四极生物电阻抗分析（BIA）进行评估。次要结局指标包括静息能量消耗、血糖、血脂、脂联素、白细胞介素6（IL-6）和胆囊收缩素水平。统计分析包括对年龄和身体活动进行校正的广义估计方程。

结果

每组评估15例患者：平均年龄为45±11岁，体重指数（BMI）为35.7±5.2 kg/m²，手术时间为69±23个月。干预组随访期间蛋白质摄入量增加约75%（p = 0.01）。与对照组相比（体重增加0.42 kg，FM增加0.6 kg），干预组体重减轻更多（1.86 kg，p = 0.017），FM减少（2.78，p = 0.021），FFM无变化。两组间次要结局指标无差异。