补充乳蛋白对炎症的影响：一项系统评价和荟萃分析。
Impacts of supplementation with milk proteins on inflammation: a systematic review and meta-analysis.
作者信息
Mohammadi Shooka, Ashtary-Larky Damoon, Mehrbod Milad, Kouhi Sough Narges, Salehi Omran Hossein, Dolatshahi Sina, Amirani Niusha, Asbaghi Omid
机构信息
Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
出版信息
Inflammopharmacology. 2025 Mar;33(3):1061-1083. doi: 10.1007/s10787-024-01615-8. Epub 2025 Jan 7.
BACKGROUND
Impacts of milk proteins (MPs) on inflammation are uncertain. The current systematic review and dose-response meta-analysis of randomized controlled trials (RCTs) evaluated the effects of whey protein (WP), casein protein (CP), or MP supplementation on serum levels of cytokines and adipokines in adults.
METHODS
A comprehensive search of various online databases was conducted to find appropriate clinical trials published until September 2024. A random-effect statistical model was implemented.
RESULTS
The meta-analysis included 53 RCTs. It was indicated that MP supplements had no substantial effects on serum values of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), adiponectin, and leptin. However, there were statistically significant decreases in serum levels of interleukin-6 (IL-6) following supplementation with MP (weighted mean difference (WMD): - 0.25 pg/mL, 95% CI - 0.48, - 0.03; P = 0.026) in the intervention group compared with the control group.
CONCLUSION
This study revealed that MP supplementation may not have any considerable impacts on the levels of cytokines and adipokines.
背景
乳蛋白（MPs）对炎症的影响尚不确定。当前对随机对照试验（RCTs）的系统评价和剂量反应荟萃分析评估了补充乳清蛋白（WP）、酪蛋白（CP）或MP对成人体内细胞因子和脂肪因子血清水平的影响。
方法
对各种在线数据库进行全面检索，以查找截至2024年9月发表的合适临床试验。采用随机效应统计模型。
结果
荟萃分析纳入了53项随机对照试验。结果表明，MP补充剂对C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、脂联素和瘦素的血清值没有实质性影响。然而，与对照组相比，干预组补充MP后血清白细胞介素-6（IL-6）水平有统计学意义的下降（加权平均差（WMD）：-0.25 pg/mL，95%CI -0.48，-0.03；P = 0.026）。
结论
本研究表明，补充MP可能对细胞因子和脂肪因子水平没有任何显著影响。
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