用于光触发药物递送和光动力治疗的阳离子肽-卟啉衍生物的灵活合成。
Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy.
作者信息
Dondi R, Yaghini E, Tewari K M, Wang L, Giuntini F, Loizidou M, MacRobert A J, Eggleston I M
机构信息
Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK.
UCL Division of Surgery and Interventional Science, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.
出版信息
Org Biomol Chem. 2016 Dec 7;14(48):11488-11501. doi: 10.1039/c6ob02135b.
Abstract
Efficient syntheses of cell-penetrating peptide-porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT).
摘要
利用多种生物共轭化学方法描述了细胞穿透肽-卟啉共轭物的高效合成。这提供了一种灵活的方法，可将本质上疏水的四吡咯光敏剂转化为两亲性衍生物，这些衍生物非常适合通过光化学内化（PCI）和靶向光动力疗法（PDT）用于光触发药物递送。
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