Dinkin Marc J, Patsalides Athos
Department of Ophthalmology, New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY, USA; Department of Neurology, New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY, USA; Department of Neurosurgery, New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY, USA.
Division of Interventional Neuroradiology, Department of Neurological Surgery, New York Presbyterian Hospital, Weill Cornell Medical College, 525 E 68th Street, New York, NY 10065, USA.
Neurol Clin. 2017 Feb;35(1):59-81. doi: 10.1016/j.ncl.2016.08.006.
Idiopathic intracranial hypertension causes headache, papilledema and visual field loss, typically in obese women of childbearing age. Its anatomical underpinnings remain unclear, but a stenosis at the junction of the transverse and sigmoid sinuses has been recognized in the majority of patients through venography. The stenosis may result from intrinsic dural sinus anatomy or extrinsic compression by increased intracranial pressure, but in either case, its stenting has been shown to lead to an improvement in symptoms of intracranial hypertension and papilledema in multiple retrospective, non-controlled studies. Prospective, controlled trials are needed to confirm its efficacy and safety.
特发性颅内高压通常发生在育龄肥胖女性身上,会导致头痛、视乳头水肿和视野缺损。其解剖学基础尚不清楚,但通过静脉造影在大多数患者中已发现横窦和乙状窦交界处存在狭窄。这种狭窄可能源于硬脑膜窦的内在解剖结构,也可能是颅内压升高引起的外在压迫,但无论哪种情况,在多项回顾性、非对照研究中均显示,对其进行支架置入可改善颅内高压和视乳头水肿的症状。需要进行前瞻性对照试验来证实其疗效和安全性。