Sathanandam Shyam, Justino Henri, Waller B Rush, Radtke Wolfgang, Qureshi Athar M
Division of Pediatric Cardiology, Department of Pediatrics, University of Tennessee Health Science Center, LeBonheur Children's Hospital, Memphis, Tennessee.
Division of Pediatric Cardiology, Department of Pediatrics, The Lillie Frank Abercrombie Section of Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.
Catheter Cardiovasc Interv. 2017 May;89(6):1051-1058. doi: 10.1002/ccd.26878. Epub 2016 Nov 26.
To describe the early multicenter, clinical experience with the Medtronic Micro Vascular Plug™ (MVP) for the occlusion of patent ductus arteriosus (PDA) in premature infants.
The MVP is a large diameter plug that can be delivered through a microcatheter for occlusion of abnormal blood vessels.
A Retrospective review of PDA embolization procedures performed in two centers using the MVP was performed.
Fifteen premature infants underwent attempted PDA occlusion using the MVP. The gestational age and birth weight were 25.6 ± 2.5 weeks and 735 ± 251 g, respectively. The median weight and age at the time of the procedure were 1,210 g (700-3,500 g) and 4.5 weeks (2-12 weeks), respectively. Median procedure and fluoroscopy times were 45 and 6.5 min, respectively. The median radiation and contrast doses were 19.7 mGy and 2.4 mL/kg, respectively. Antegrade occlusion was successfully achieved in 13 patients <2 kg with only femoral venous access aided by echo guidance. The two patients >2 kg had arterial access and attempted retrograde occlusion; one of which was unsuccessful due to the PDA being short and wide. Complete closure was observed in 13 of 14 successful procedures (93%), with one patient having a small residual shunt that was not seen on follow-up. There were no complications related to the procedure or noted during follow-up (Median 11 months).
The MVP is a new, large-diameter vascular embolization device that may be useful for the occlusion of PDA in extremely small, premature infants. © 2016 Wiley Periodicals, Inc.
描述美敦力微血管封堵器™（MVP）用于早产儿动脉导管未闭（PDA）封堵的早期多中心临床经验。
MVP是一种大口径封堵器，可通过微导管输送以封堵异常血管。
对在两个中心使用MVP进行的PDA栓塞手术进行回顾性研究。
15例早产儿尝试使用MVP封堵PDA。胎龄和出生体重分别为25.6±2.5周和735±251克。手术时的中位体重和年龄分别为1210克（700 - 3500克）和4.5周（2 - 12周）。中位手术时间和透视时间分别为45分钟和6.5分钟。中位辐射剂量和造影剂剂量分别为19.7毫戈瑞和2.4毫升/千克。13例体重<2千克的患者仅通过股静脉入路在超声引导下成功实现顺行封堵。2例体重>2千克的患者采用动脉入路尝试逆行封堵；其中1例因PDA短而宽封堵失败。1,4例成功手术中有13例（93%）实现完全封堵，1例患者有小的残余分流，随访时未发现。手术及随访期间（中位时间11个月）均无相关并发症。
MVP是一种新型大口径血管栓塞装置，可能对极小的早产儿PDA封堵有用。©2016威利期刊公司
