有自残行为的年轻女性在面对心理社会压力源时皮质醇水平较低。
Lower cortisol level in response to a psychosocial stressor in young females with self-harm.
作者信息
Plener Paul L, Zohsel Katrin, Hohm Erika, Buchmann Arlette F, Banaschewski T, Zimmermann Ulrich S, Laucht Manfred
机构信息
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany.
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany.
出版信息
Psychoneuroendocrinology. 2017 Feb;76:84-87. doi: 10.1016/j.psyneuen.2016.11.009. Epub 2016 Nov 14.
BACKGROUND
Self-harm is highly prevalent in adolescence, often serving an emotion regulation function. Social stressors such as bullying are associated with self-harm. The neurobiological background of the relationship between social stressors and self-harm needs to be further understood to inform prevention and therapy.
METHODS
Participants were members of an epidemiological cohort study. 130 female participants underwent the Trier Social Stress Test (TSST) at age 19. Of them, 21 reported a history of self-harm as assessed by the Youth Self Report. Psychiatric diagnoses were recorded.
RESULTS
Participants with a history of self-harm showed significantly lower blood cortisol levels throughout the TSST. Early psychosocial adversity did not significantly differ between groups with and without self-harm, with self-harming participants reporting more childhood adversities.
CONCLUSION
These results add to the limited field of studies showing an altered HPA axis activity in females with self-harm. Future studies need to address the causal mechanisms behind this association.
背景
自我伤害在青少年中极为普遍，通常起到情绪调节的作用。诸如欺凌等社会压力源与自我伤害相关。社会压力源与自我伤害之间关系的神经生物学背景有待进一步了解，以便为预防和治疗提供依据。
方法
参与者是一项流行病学队列研究的成员。130名女性参与者在19岁时接受了特里尔社会应激测试（TSST）。其中，根据青少年自我报告评估，有21人报告有自我伤害史。记录了精神疾病诊断情况。
结果
有自我伤害史的参与者在整个TSST过程中血液皮质醇水平显著较低。有或无自我伤害史的两组之间，早期心理社会逆境没有显著差异，但有自我伤害行为的参与者报告的童年逆境更多。
结论
这些结果为有限的研究领域增添了内容，表明有自我伤害行为的女性下丘脑-垂体-肾上腺（HPA）轴活动发生了改变。未来的研究需要探讨这种关联背后的因果机制。
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