Section for Disorders of Personality Development, Department of Child and Adolescent Psychiatry, Centre of Psychosocial Medicine, University of Heidelberg, Blumenstrasse 8, 69115 Heidelberg, Germany.
Psychoneuroendocrinology. 2012 Jan;37(1):157-61. doi: 10.1016/j.psyneuen.2011.05.009. Epub 2011 Jun 15.
To investigate the neuroendocrinological stress response to acute psychosocial stress in a clinical sample of female adolescents engaging in nonsuicidal self-injury (NSSI).
The Trier Social Stress Test (TSST), a standardized psychosocial stress protocol, was performed in 14 female patients who engaged in NSSI and 14 healthy control subjects. NSSI was assessed by the Functional Assessment of Self-Mutilation (FASM). Salivary cortisol, heart rate, and affective states, assessed by the Positive and Negative Affect Schedule (PANAS), were measured during the TSST.
We found an attenuated cortisol response to acute psychosocial stress in female adolescents with NSSI, whereas no group differences were observed in heart rate and emotional response to the TSST.
These findings indicate that the HPA axis is hyporesponsive in adolescents with NSSI. Therefore, reduced secretion of cortisol could play a role in promoting vulnerability of these individuals to acute stress and maladaptive stress responses.
在参与非自杀性自伤（NSSI）的女性青少年临床样本中，研究神经内分泌应激反应对急性心理社会应激的影响。
对 14 名 NSSI 患者和 14 名健康对照者进行了 Trier 社会应激测试（TSST），这是一种标准化的心理社会应激方案。通过功能评估自伤（FASM）评估 NSSI。在 TSST 期间测量唾液皮质醇、心率和正性和负性情绪量表（PANAS）评估的情感状态。
我们发现，NSSI 女性青少年对急性心理社会应激的皮质醇反应减弱，而在心率和对 TSST 的情绪反应方面，两组之间没有差异。
这些发现表明，HPA 轴在 NSSI 青少年中反应迟钝。因此，皮质醇分泌减少可能在促进这些个体对急性应激和适应不良的应激反应的脆弱性方面发挥作用。
