Szabó Andrea, Janovszky Ágnes, Pócs Levente, Boros Mihály
Institute of Surgical Research, University of Szeged, Szeged, Hungary.
Department of Oral and Maxillofacial Surgery, University of Szeged, Szeged, Hungary.
Microvasc Res. 2017 Mar;110:5-13. doi: 10.1016/j.mvr.2016.11.005. Epub 2016 Nov 23.
Apart from its nutritive functions, the periosteum critically affects bone regeneration via its stem/osteoprogenitor cell content. Normal healing after bone fractures, trauma-orthopedic interventions and invasive dental procedures is critically linked to the reestablishment of the periosteal microcirculation, but the reconstruction, replacement or repair of lost tissues may also be performed with autologous periosteum. Besides the initiation of cell differentiation during bone repair and remodeling processes, the periosteum together with the endosteum plays significant roles in the pathogenesis of both hormone-related and trauma-induced osteoporotic alterations in the bone metabolism. Nevertheless, the axial bones, and in particular the jawbones, and the appendicular bones display differences not only in their blood supply and fracture healing characteristics, but also in respect of the development of osteoporosis and their reactions to treatment modalities (i.e. bisphosphonates). These reactions may also be linked to the differences in periosteal microcirculatory reactions. The present overview summarizes the relevant data of microcirculatory studies focusing on the periosteal reactions in different anatomical locations together with the optimal background methodologies, study models and the most significant observations.
除了其营养功能外，骨膜通过其干细胞/骨祖细胞成分对骨再生有至关重要的影响。骨折、创伤骨科干预和侵入性牙科手术后的正常愈合与骨膜微循环的重建密切相关，但丢失组织的重建、置换或修复也可用自体骨膜进行。除了在骨修复和重塑过程中启动细胞分化外，骨膜与骨内膜在激素相关和创伤诱导的骨代谢骨质疏松改变的发病机制中都起着重要作用。然而，中轴骨，尤其是颌骨和附属骨，不仅在血液供应和骨折愈合特征方面存在差异，而且在骨质疏松的发展及其对治疗方式（即双膦酸盐）的反应方面也存在差异。这些反应也可能与骨膜微循环反应的差异有关。本综述总结了微循环研究的相关数据，重点关注不同解剖部位的骨膜反应，以及最佳的背景方法、研究模型和最重要的观察结果。
