Sex differences in insulin sensitivity and insulin response with increasing age in black South African men and women.

AIMS

Black Africans are disproportionally affected by type 2 diabetes, but the pathophysiology is poorly understood. The study aimed to examine the effect of sex and age on insulin sensitivity and insulin response in black South African adults.

METHODS

This cross-sectional study included a random sample of 179 men and 260 women aged 25-74years with normal glucose tolerance from 5 peri-urban townships in Cape Town, SA. Insulin sensitivity (insulin sensitivity index, ISI) and response (insulinogenic index, IGI), and the disposition index (DI, ISI×IGI), derived from an oral glucose tolerance test, were measured.

RESULTS

Although men were older (median [interquartile range]: 39 [30-48] vs. 35 [29-44], P=0.021) and had significantly lower BMI than women (22.6 [20.0-25.3] vs. 31.0 [25.9-35.7] kg/m, P=0.001), DI was not different (P=0.740), but ISI was higher (P=0.007) and IGI was lower (P=0.074) in men than women, adjusting for age and BMI. With increasing age, DI (β (95%CI): -24.4 (-36.3 to -12.5), P<0.001) and IGI (β (95%CI): -4.9 (-7.5 to -2.2), P<0.001) decreased similarly in both sexes, but ISI did not change (β (95%CI): 0.005 (-0.20 to 0.03), P=0.675).

CONCLUSION

Black South African women with normal glucose tolerance have lower insulin sensitivity than their male counterparts, but increase their insulin response to maintain normoglycemia. With increasing age, insulin sensitivity remains unchanged, but the insulin response decreases at a similar rate in men and women.