白细胞介素-22与环孢素治疗侵袭性皮肤鳞状细胞癌
Interleukin-22 and Cyclosporine in Aggressive Cutaneous Squamous Cell Carcinoma.
作者信息
Santana Alexis L, Felsen Diane, Carucci John A
机构信息
The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.
Institute for Pediatric Urology, Department of Urology, Weill Cornell Medical College, 1300 York Avenue, Box 94, New York, NY 10065, USA.
出版信息
Dermatol Clin. 2017 Jan;35(1):73-84. doi: 10.1016/j.det.2016.07.003.
Abstract
Cutaneous squamous cell carcinomas (SCCs) account for up to 10,000 deaths annually in the United States. Most of the more than 700,000 SCCs diagnosed are cured by excision with clear margins; however, metastasis can occur despite seemingly adequate treatment in some cases. Immune-suppressed organ transplant recipients are 60 to 100 times more likely to develop SCC than immune-competent individuals. Transplant-associated SCCs occur more frequently and behave more aggressively, showing higher risk of recurrence and metastasis. This article identifies a potential role for interleukin-22 in driving SCC proliferation, particularly in solid organ transplant recipients taking cyclosporine.
摘要
皮肤鳞状细胞癌（SCC）在美国每年导致多达10000人死亡。在每年诊断出的70多万例SCC中，大多数通过切缘阴性的切除手术得以治愈；然而，在某些情况下，尽管治疗看似充分，仍可能发生转移。免疫抑制的器官移植受者患SCC的可能性比免疫功能正常的个体高60至100倍。与移植相关的SCC发生频率更高，侵袭性更强，复发和转移风险更高。本文确定了白细胞介素-22在驱动SCC增殖中的潜在作用，特别是在服用环孢素的实体器官移植受者中。
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本文引用的文献
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Cyclosporine A immunosuppression drives catastrophic squamous cell carcinoma through IL-22.环孢素 A 免疫抑制通过 IL-22 驱动灾难性鳞状细胞癌。
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