Mao-Draayer Yang, Sarazin Jeffrey, Fox David, Schiopu Elena
Department of Neurology and Clinical Autoimmunity Center of Excellence, University of Michigan Medical School, 4015 Alfred Taubman Biomedical Sciences Research Bldg., 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, United States.
Department of Neurology and Clinical Autoimmunity Center of Excellence, University of Michigan Medical School, 4015 Alfred Taubman Biomedical Sciences Research Bldg., 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, United States.
Clin Immunol. 2017 Feb;175:10-15. doi: 10.1016/j.clim.2016.11.008. Epub 2016 Nov 23.
Multiple sclerosis (MS) is a prototype autoimmune disease of the central nervous system (CNS). Currently, there is no drug that provides a cure for MS. To date, all immunotherapeutic drugs target relapsing remitting MS (RR-MS); it remains a daunting medical challenge in MS to develop therapy for secondary progressive MS (SP-MS). Since the approval of the non-selective sphingosine-1-phosphate (S1P) receptor modulator FTY720 (fingolimod [Gilenya®]) for RR-MS in 2010, there have been many emerging studies with various selective S1P receptor modulators in other autoimmune conditions. In this article, we will review how S1P receptor may be a promising therapeutic target for SP-MS and other autoimmune diseases such as psoriasis, polymyositis and lupus.
多发性硬化症(MS)是中枢神经系统(CNS)的一种典型自身免疫性疾病。目前,尚无药物能够治愈MS。迄今为止,所有免疫治疗药物均针对复发缓解型MS(RR-MS);开发继发进展型MS(SP-MS)的治疗方法仍是MS领域一项艰巨的医学挑战。自2010年非选择性鞘氨醇-1-磷酸(S1P)受体调节剂FTY720(芬戈莫德[捷灵亚®])获批用于RR-MS以来,在其他自身免疫性疾病中,针对各种选择性S1P受体调节剂开展了许多新出现的研究。在本文中,我们将综述S1P受体如何可能成为SP-MS及其他自身免疫性疾病(如银屑病、多发性肌炎和狼疮)的一个有前景的治疗靶点。